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CAS RN: 1445-07-4 | 产品编码: P2396
Pseudouridine
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| 产品编码 | P2396 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__9H__1__2N__2O__6 = 244.20 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1445-07-4 |
| Reaxys-RN | 621385 |
| PubChem物质ID | 354334120 |
| MDL编号 | MFCD00038458 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 10.90 to 12.00 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 231 °C(dec.) |
| 最大吸收波长 | 264(MeOH) nm |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
Pseudouridine: The Most Common Modified Nucleoside in RNA
Pseudouridine (5-ribosyluracil, abbreviated by the Greek letter psi- Ψ), the most common modified nucleoside in RNA, is the C-glycoside isomer of the ribonucleoside uridine [U0020]. Pseudouridine is biosynthesized from uridine via the action of pseudouridine synthases in vivo. Nowadays, pseudouridine is identified as a fifth nucleoside in RNA. Pseudouridine is found in lots of tRNAs and rRNAs but never in mRNA. However, recently it has been reported that artificial pseudouridylation dramatically affects mRNA function. The function of pseudouridine is currently not clear, but it is assumed that pseudouridine plays a role in association with RNA stability and/or helping aminoacyl transferases interact with tRNAs.
References
- Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs
- Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA
- Pseudouridine in RNA: what, where, how, and why (a review)
- Ribosomal RNA pseudouridines and pseudouridine synthases (a review)
- Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
- Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
参考文献
Please visit the Pubchem page at this link.
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