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CAS RN: 59-33-6 | 产品编码: P2369
Pyrilamine Maleate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 100.0 to 104.0 °C |
物性（参考值）
| 熔点 | 102 °C |
| 最大吸收波长 | 310 nm (EtOH) |
| 水溶性 | 可溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | UT1225000 |
运输信息
| HS编码* | 2933.39-000 |
应用
Pyrilamine Maleate: A First Generation Histamine H1 Receptor Antagonist
Pyrilamine maleate, also known as pyrilamine maleate, is a first generation histamine H1 receptor antagonist. Pyrilamine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Pyrilamine permeates the blood-brain barrier causing drowsiness. Pyrilamine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271], chlorpheniramine maleate [C0873] and bromopheniramine maleate [B5167]. (The product is for research purpose only.)
References
- Physical and biological properties of pyrilamine (a review)
- Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists
- Influence of certain H1-blockers on the step-through active avoidance response in rats
- Mepyramine, a Histamine H1 Receptor Inverse Agonist, Binds Preferentially to a G Protein-coupled Form of the Receptor and Sequesters G Protein
- Delineation of receptor-ligand interactions at the human histamine H1 receptor by a combined approach of site- directed mutagenesis and computational techniques - or - how to bind the H1 receptor (a review)
- Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography
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