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CAS RN: 34183-22-7 | 产品编码: P2301
Propafenone Hydrochloride
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| 产品编码 | P2301 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__7NO__3·HCl = 377.91 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 34183-22-7 |
| 相关CAS RN | 54063-53-5 |
| Reaxys-RN | 4343069 |
| PubChem物质ID | 253660866 |
| Merck Index (14) | 7794 |
| MDL编号 | MFCD00079243 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 171.0 to 175.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 173 °C |
| 最大吸收波长 | 303 nm (MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | UH2833000 |
运输信息
| HS编码* | 2922.50-000 |
应用
Propafenone Hydrochloride: A Sodium Channel Antagonist (Blocker)
Propafenone hydrochloride is an orally active sodium channel antagonist (blocker). Propafenone works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitability of the cells. Moreover, propafenone also has β-adrenoceptor antagonist, potassium channel antagonist, and weak calcium channel antagonist activity. Propafenone is used as a class Ic antiarrhythmic agent. (The product is for research purpose only.)
References
- Propafenone (a review on the pharmacology of the antiarrhythmic agent propafenone in humans and laboratory animals.)
- Propafenone. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in cardiac arrhythmias (a review)
- Potassium channel blocking properties of propafenone in rabbit atrial myocytes
- Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry
参考文献
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