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CAS RN: 635702-64-6 | 产品编码: P2243
Pazopanib Hydrochloride
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| 产品编码 | P2243 |
| 纯度/分析方法 | >95.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__3N__7O__2S·HCl = 473.98 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿),加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 635702-64-6 |
| PubChem物质ID | 468592583 |
| MDL编号 | MFCD12546138 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Water | max. 3.0 % |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Pazopanib Hydrochloride: An Oral Small Molecule Multi-Tyrosine Kinase Inhibitor
Pazopanib hydrochloride (GW786034B) is an oral small molecule multi-tyrosine kinase inhibitor. It has been demonstrated that pazopanib shows inhibitory action for vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR)-α and β, fibroblast growth factor receptor (FGFR)-1 and -3, cytokine receptor (Kit), interleukin-2 receptor-inducible T-cell kinase (Itk), lymphocyte-specific protein-tyrosine kinase (Lck), and transmembrane glycoprotein receptor tyrosine kinase (c- Fms). Pazopanib is thought to inhibit tumor growth by inhibiting the activation of VEGFR and PDGFR related to angiogenesis, which is involved in tumor growth. (The product is for research purpose only.)
References
- The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
- Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor
- Pazopanib: a novel multitargeted tyrosine kinase inhibitor (a review)
- Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? (a review)
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