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CAS RN: 55268-74-1 | 产品编码: P2125
Praziquantel
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 137.0 to 141.0 °C |
物性（参考值）
| 熔点 | 140 °C |
| 最大吸收波长 | 271 nm |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.4 g/l |
| 溶解性（可溶于） | 甲醇, 乙醇 |
GHS
| 危险性说明 | H402 : Harmful to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | UQ4150000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Praziquantel: An Anthelmintic Agent for Schistosoma and Liver Fluke
Praziquantel (abbr.: PZQ), an anthelmintic agent, is used to treat schistosoma and liver fluke from 1980s. Although its mechanism of action remains unknown exactly, there are some reports that PZQ increases the permeability of the membranes of schistosoma cells towards calcium ions. PZQ thereby induces contraction of the schistosoma, resulting in paralysis in the contracted state.
References
- Praziquantel (a review)
- Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers
- PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution
- Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
参考文献
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