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CAS RN: 1263-89-4 | 产品编码: P2092
Paromomycin Sulfate
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| 产品编码 | P2092 |
| 纯度/分析方法 | >92.0%(HPLC) |
| 分子式/分子量 | C__2__3H__4__5N__5O__1__4·xH__2SO__4 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1263-89-4 |
| 相关CAS RN | 7542-37-2&84420-34-8 |
| PubChem物质ID | 253662559 |
| Merck Index (14) | 7041 |
| MDL编号 | MFCD00079278 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 92.0 area% |
| Specific rotation [a]20/D | +47.0 to +55.0 deg(C=1, H2O) |
物性（参考值）
| 比旋光度 [α]D | 48° (C=1,H2O) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | WK2320000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Paromomycin: An Aminoglycoside Antibiotic against Bacteria, Protozoa and Cestodes
Paromomycin is an aminoglycoside antibiotic, first isolated from various Streptomyces in the 1950s. It is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin irreversibly binds to the 30S subunit (16S rRNA) of the bacterial ribosome as with any other aminoglycoside antibiotics, and then it inhibits bacterial growth by inhibiting protein synthesis. Paromomycin is mainly used for treatment of leishmaniasis and amoebic dysentery. (The product is for research purpose only.)
References
- Comparisons of ribosomal RNA sequences from amitochondrial protozoa: implications for processing, mRNA binding and paromomycin susceptibility
- The conformation of ribosomes and rRNA (a review)
- rRNA chemical groups required for aminoglycoside binding
- Paromomycin in the treatment of leishmaniasis
- Paromomycin (a review)
- A chemical assessment and HPLC assay validation of bulk paromomycin sulfate
参考文献
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