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CAS RN: 284461-73-0 | 产品编码: O0599
Sorafenib
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 500MG |
S$394.50
|
5 | 21 | 下单后约2周内可以发货 |
|
| 产品编码 | O0599 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__1__6ClF__3N__4O__3 = 464.83 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 284461-73-0 |
| Reaxys-RN | 9666200 |
| MDL编号 | MFCD06411450 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 203.0 to 207.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 205 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | US4588870 |
运输信息
| HS编码* | 2933.39-000 |
应用
Sorafenib: An Inhibitor of Multiple Protein Kinases
The Ras/Raf/MEK/ERK signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. Sorafenib (BAY 43-9006) inhibits intracellular Raf kinases (C-Raf, B-Raf and mutant B-Raf) and cell surface receptor tyrosine kinases (c-KIT, FLT- 3, RET, VEGFR-1, VEGFR- 2, VEGFR- 3, and PDGFR).1-4) Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis and apoptosis. In fact, sorafenib decreases tumor cell proliferation and angiogenesis in vitro. There are reports, that sorafenib also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.5) (The product is for research purpose only.)
References
- 1) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
- 2) Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5
- 3) Discovery and development of sorafenib: a multikinase inhibitor for treating cancer (a review)
- 4) Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling (a review)
- 5) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
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![Sorafenib [Optimized for Cell Culture]](/medias/Tci-300-O0672.jpg?context=bWFzdGVyfHJvb3R8OTI4MnxpbWFnZS9qcGVnfGFEZGhMMmd6T0M4NU5EZzRPRGt6TURVd09URXdMMVJqYVMwek1EQmZUekEyTnpJdWFuQm58MWVkNTVhYmIyMjYxNTU3Y2E0NmUxOTE4NDA0MWM4NzQzOWViYjkwMGVhMWVlYmMzOGFjYmMxMmEyMzQ4MjNiMg "Sorafenib [Optimized for Cell Culture]")