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CAS RN: 144689-63-4 | 产品编码: O0510
Olmesartan Medoxomil
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| 产品编码 | O0510 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__9H__3__0N__6O__6 = 558.60 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 144689-63-4 |
| Reaxys-RN | 7506931 |
| PubChem物质ID | 354335790 |
| Merck Index (14) | 6839 |
| MDL编号 | MFCD00944911 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 180 °C(dec.) |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇, 丙酮 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | NI4014200 |
运输信息
| HS编码* | 2934.99-000 |
应用
Olmesartan Medoxomil: A Prodrug of Olmesartan, a Selective AT1 Subtype Angiotensin II Receptor Antagonist
Olmesartan medoxomil (CS-866), a prodrug, is hydrolyzed to the active metabolite olmesartan [O0507] during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist (“sartan”). Olmesartan medoxomil is used for the treatment of hypertension. (The product is for research purpose only.)
References
- Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist
- Real-time monitoring of metabolic reactions by microdialysis in combination with tandem mass spectrometry: hydrolysis of CS-866 in vitro in human and rat plasma, livers, and small intestines
- Hydrolysis of angiotensin II receptor blocker prodrug olmesartan medoxomil by human serum albumin and identification of its catalytic active sites
参考文献
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