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CAS RN: 751-03-1 | 产品编码: O0506
Obacunone
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纯度/分析方法: >98.0%(HPLC)
别名：
- 黄柏酮
- 黄柏酮酸ε-内酯
- 黄柏酮酸3,4-内酯
- (1S,3aS,4aR,4bR,6aR,11aR,11bR,13aS)-1-(呋喃-3-基)-4b,7,7,11a,13a-五甲基-1,6a,7,11a,11b,12,13,13a-八氢恶庚因并[4',3':3,4]苯并[1,2-f]环氧乙烯并[2,3-d]异苯并吡喃-3,5,9(3aH,4bH,6H)-三酮
- Obacunoic Acid ε-Lactone
- Obacunoic Acid 3,4-Lactone
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产品文档：
| 产品编码 | O0506 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__6H__3__0O__7 = 454.52 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 751-03-1 |
| 相关CAS RN | 6483-15-4 |
| Reaxys-RN | 68347 |
| MDL编号 | MFCD00075888 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 227.0 to 231.0 °C |
| Specific rotation | -49.0 to -53.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 229 °C |
GHS
相关法规
| RTECS# | RR1104200 |
运输信息
| HS编码* | 2932.20-000 |
应用
Obacunone: A Type of Limonoid with Various Pharmacological Activities Such As Anticancer and Anti-Inflammatory
Limonoids are a class of oxygenated terpenoids found primarily in citrus fruits. Obacunone is a type of limonoid with various pharmacological activities such as anticancer, antioxidant, anti-inflammatory, antidiabetic, neuroprotective, antibiosis, and antiviral. Among them, the anticancer effect is the most prominent. (The product is for research purpose only.)
References
- The pharmacological and pharmacokinetic properties of obacunone from citrus fruits: A comprehensive narrative review
- Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis
- Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF
- Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract
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