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CAS RN: 75629-57-1 | 产品编码: O0450
Oncrasin 1
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技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 4.90 to 5.50 % |
| Melting point | 115.0 to 119.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 117 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
RNAポリメラーゼII阻害剤，オンクラシン1
Oncrasin 1 is a RNA polymerase II inhibitor with antitumor activity. Oncrasin 1 analogs have been studied to improve the activity.
References
- 1)Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota
- 2)Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)
- 3)Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities
参考文献