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CAS RN: 28721-07-5 | 产品编码: O0363
Oxcarbazepine
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技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
物性（参考值）
| 熔点 | 216 °C(dec.) |
| 溶解性（可溶于） | 二甲基甲酰胺 |
GHS
相关法规
| RTECS# | HN8445000 |
运输信息
| HS编码* | 2933.99-000 |
应用
電位依存性ナトリウムチャネル (VGSC) 阻害剤，オクスカルバゼピン
Oxcarbazepine is an antiepileptic agent with a chemical structure similar to carbamazepine [CAS: 298-46-4], adding an extra oxygen atom to the benzylcarboxamide group. Oxcarbazepine was developed to improve the side effect profile of carbamazepine. Oxcarbazepine is rapidly metabolized to 10,11-dihydro-10-hydroxycarbazepine (monohydroxy derivative, MHD) which also has the pharmacological activity. The precise mechanism of action is unknown, but in vitro studies indicate that oxcarbazepine and MHD produce blockade of voltage-sensitive sodium channels (VGSC), resulting in stabilization of hyperexcited neural membranes. (The product is for research purpose only.)
References
- Oxcarbazepine: an update of its efficacy in the management of epilepsy (a review)
- Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093 (eslicarbazepine acetate [E1046]), and BIA 2-024 (a review)
- Clinical pharmacokinetics of oxcarbazepine (a review)
- Enantioselective pharmacokinetics of 10-hydroxycarbazepine after oral administration of oxcarbazepine to healthy Chinese subjects
- The use of separation techniques in the analysis of some antiepileptic drugs: A critical review
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