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CAS RN: 503468-95-9 | 产品编码: N1110
NU 7441
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| 产品编码 | N1110 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__5H__1__9NO__3S = 413.49 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 503468-95-9 |
| Reaxys-RN | 9876245 |
| MDL编号 | MFCD11983069 |
技术规格
| Appearance | White to Gray to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.00 to 3.80 % |
物性（参考值）
| 熔点 | 222 °C(dec.) |
| 最大吸收波长 | 233(EtOH) nm |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
CRISPR Genome Editing
DNA-dependent protein kinase (DNA-PK) inhibitor, NU 7441, reduces the frequency of non-homologous end joining (NHEJ) while increasing the rate of homology-directed recombination (HDR) following Cas9-mediated DNA cleavage.1)
References
- 1) Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
应用
NU7441: DNA-dependent protein kinase (DNA-PK) inhibitor
Recently, the inhibition of DNA repair is emerging as a new therapeutic strategy for cancer treatment. NU7441 (KU57788) is a potent and selective inhibitor of the DNA repair enzyme DNA-dependent protein serine/threonine kinase (DNA-PK) which is activated by DNA damage and mediates DNA double-strand break repair. (The product is for research purpose only.)
References
- Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
- Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach
- Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441
- DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
- Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
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