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CAS RN: 55981-09-4 | 产品编码: N1031
Nitazoxanide
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | N1031 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__2H__9N__3O__5S = 307.28 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 55981-09-4 |
| Reaxys-RN | 1225475 |
| PubChem物质ID | 354333058 |
| Merck Index (14) | 6567 |
| MDL编号 | MFCD00416599 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 198.0 to 202.0 °C |
物性（参考值）
| 熔点 | 200 °C |
| 最大吸收波长 | 416 nm (Phosphate buffer sol.) |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | VN7830000 |
运输信息
| HS编码* | 2934.10-000 |
应用
Nitazoxanide: A Thiazolide Antiprotozoal and Antiviral Agent
Nitazoxanide is originally developed as a thiazolide antiprotozoal agent that shows excellent in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths. Nitazoxanide is a prodrug, and following oral administration in animals, nitazoxanide is rapidly hydrolyzed to an active metabolite, tizoxanide [T3862] (desacetyl-nitazoxanide) by esterase. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Recently, antiviral activity of nitazoxanide against a broad range of other RNA and DNA viruses such as hepatitis B virus, hepatitis C virus and influenza virus has been recognized in in vitro systems. Nitazoxanide is synergistic with neuraminidase inhibitors, and also inhibits the replication of a broad range of viruses. (The product is for research purpose only.)
References
- In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
- Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models
- Nitazoxanide: a new thiazolide antiparasitic agent (a review)
- Nitazoxanide a review of its use in the treatment of gastrointestinal infections
- Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
- Nitazoxanide: A first-in-class broad-spectrum antiviral agent (a review)
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