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CAS RN: 161058-83-9 | 产品编码: N0958
NU 2058
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 27.00 to 29.50 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 199 °C |
| 最大吸收波长 | 281(MeOH) nm |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
サイクリン依存性キナーゼ阻害因子(阻害剤)，NU2058
O-Cyclohexylmethylguanine (NU2058) is an ATP competitive cyclin-dependent kinases (CDK1 and CDK2) inhibitor which inhibits the function of the kinases. Cyclin-dependent kinases (CDKs) are a group of protein kinases that are activated by the formation of a complex with a cyclin and are involved in the regulation of the cell cycle. Aberrant control of CDKs is a central feature of the molecular pathology of cancer cell, and in recent years CDKs are targeted for anti-cancer drugs.
References
- Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles
- Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
- Cyclin-dependent kinase modulators studied at the NCI: Pre-clinical and clinical studies (a review)
- N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2
- Insights into the Structural Basis of N2 and O6 Substituted Guanine Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors: Prediction of the Binding Modes and Potency of the inhibitors by Docking and ONIOM Calculations
参考文献
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