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CAS RN: 129618-40-2 | 产品编码: N0922
Nevirapine
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 200MG |
S$163.50
|
15 | ≥60 |
|
| 1G |
S$519.00
|
1 | 1 |
|
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | N0922 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__1__5H__1__4N__4O = 266.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 129618-40-2 |
| Reaxys-RN | 4757598 |
| PubChem物质ID | 160871291 |
| Merck Index (14) | 6490 |
| MDL编号 | MFCD00866928 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 244.0 to 248.0 °C |
物性（参考值）
| 熔点 | 246 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | < 0.1 g/l |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | JM5562500 |
运输信息
| HS编码* | 2933.99-000 |
应用
Nevirapine: A Non-Nucleoside Reverse Transcriptase Inhibitor
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that active against HIV-1. Nevirapine selectively inhibits HIV-1 but not HIV-2 and any of the human DNA polymerases. Nucleoside reverse transcriptases (NRTIs) compete with natural nucleic acid triphosphates for inhibitory action, whereas nevirapine does not compete with the triphosphates. Nevirapine bind to an active site of the reverse transcriptase molecule of HIV-1, and inhibits the transcriptase activity. Therefore, nevirapine is also active against NRTI (e.g. azidothymidine) resistant HIV-1. (The product is for research purpose only.)
References
- Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
- Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
- Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
- Nevirapine: a review of its development, pharmacological profile and potential for clinical use
参考文献
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