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CAS RN: 75530-68-6 | 产品编码: N0899
Nilvadipine
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纯度/分析方法: >95.0%(N)
别名：
- 尼伐地平
- 2-氰基-1,4-二氢-6-甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸-5-异丙基-3-甲酯
- 5-异丙基-3-甲基-2-氰基-1,4-二氢-6-甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸酯
- 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester
- 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
产品文档：
| 产品编码 | N0899 |
| 纯度/分析方法 | >95.0%(N) |
| 分子式/分子量 | C__1__9H__1__9N__3O__6 = 385.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 75530-68-6 |
| Reaxys-RN | 3572609 |
| PubChem物质ID | 135727167 |
| Merck Index (14) | 6545 |
| MDL编号 | MFCD00867065 |
技术规格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Melting point | 149.0 to 153.0 °C |
物性（参考值）
| 熔点 | 151 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（微溶于） | 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相关法规
| RTECS# | US7968300 |
运输信息
| HS编码* | 2933.39-000 |
应用
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，ニルバジピン
Nilvadipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nilvadipine have a longer duration of action and a greater vasodilatory effect. Nilvadipine is mainly metabolized by CYP3A4 in the liver. Nilvadipine is a poorly water soluble agent, and its solid dispersions have been developed to the solubility. (The product is for research purpose only.)
References
- Effects of nilvadipine on the cardiovascular system in experimental animals
- Effects of nilvadipine, a new calcium entry blocker, on systemic blood pressure, cardiac hypertrophy and venous distensibility in spontaneously hypertensive rats
- Nilvadipine: profile of a new calcium antagonist. An overview
- Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions
- Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropyl methyl cellulose
- Stability study of nilvadipine in bulk drug and pharmaceutical capsules by high performance liquid chromatography
参考文献
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