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CAS RN: 91421-42-0 | 产品编码: N0822
9-Nitrocamptothecin
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 100MG |
S$439.50
|
17 | 20 | 下单后约3-4周内可以发货 |
|
| 产品编码 | N0822 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__0H__1__5N__3O__6 = 393.36 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 91421-42-0 |
| Reaxys-RN | 5365063 |
| PubChem物质ID | 87560509 |
| Merck Index (14) | 8288 |
| MDL编号 | MFCD06656294 |
技术规格
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +36.0 to +42.0 deg(C=0.4, CHCl3:MeOH=8:2) |
物性（参考值）
| 熔点 | 268 °C |
| 比旋光度 [α]D | 39° (C=0.4,CHCl3:MeOH=8:2) |
GHS
相关法规
运输信息
| HS编码* | 2939.79-000 |
应用
水不溶性のトポイソメラーゼ I阻害剤，9-ニトロカンプトテシン (9-NC)
9-Nitrocamptothecin (9-NC) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. Its metabolite is 9-aminocamptothecin [A2063]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.
References
- Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity
- Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin
- Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
- Encapsulation of 9-nitrocamptothecin, a novel anticancer drug, in biodegradable nanoparticles: factorial design, characterization and release kinetics
- The camptothecins (a review)
- Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high- performance liquid chromatography with ultraviolet and fluorescence detection
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