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CAS RN: 77086-22-7 | 产品编码: M3393
(+)-MK 801 Maleate
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| 产品编码 | M3393 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__6H__1__5N·C__4H__4O__4 = 337.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器 | 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 77086-22-7 |
| Reaxys-RN | 7158220 |
| PubChem物质ID | 468592439 |
| MDL编号 | MFCD00082465 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +115 to +121 deg(C=0.6, ｴﾀﾉｰﾙ) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 210 °C |
GHS
相关法规
| RTECS# | HP1093575 |
运输信息
| HS编码* | 2933.49-000 |
应用
(+)-MK 801 maleate: A Potent, Selective and Non-Competitive N-methyl-D-aspartate (NMDA) receptor antagonist
(+)-MK 801 maleate (its other name: dizocilpine maleate) is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, and has been reported to display various physiological effects, mainly involving the central nervous system.1-3) Therefore, (+)-MK 801 maleate has been used as an important tool for the screening of antipsychotic potential of new compounds.4) (The product is for research purpose only.)
References
- 1) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist
- 2) Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
- 3) Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity (a review)
- 4) Consequences of early life MK-801 administration: Long-term behavioural effects and relevance to schizophrenia research (a review)
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