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CAS RN: 13860-38-3 | 产品编码: M3387
1-Methylpseudouridine
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纯度/分析方法: >99.0%(HPLC)
别名：
- 1-甲基假尿苷
- 1-甲基-5-β-D-呋喃核糖尿嘧啶
- 1-甲基-5-β-D-呋喃核糖基-2,4(1H,3H)-嘧啶二酮
- (1S)-1,4-脱水-1-(1-甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-核糖醇
- 1-Methyl-5-β-D-ribofuranosyluracil
- 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
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产品文档：
| 产品编码 | M3387 |
| 纯度/分析方法 | >99.0%(HPLC) |
| 分子式/分子量 | C__1__0H__1__4N__2O__6 = 258.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 13860-38-3 |
| Reaxys-RN | 551569 |
| MDL编号 | MFCD10687017 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 187.0 to 191.0 °C |
| Specific rotation | -6.0 to -8.0 deg (C=1, water) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 189 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
1-Methylpseudouridine (m1Ψ): A Non-Natural Pyrimidine Nucleoside Found in mRNA Vaccines
In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development1). Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses. In protein biosynthesis, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) [P2939 (synthetic)] [P2396] are read like uridine (U) and enable comparatively high protein yields. Furthermore, m1Ψ enhances immune evasion, protein production, and consequently vaccine efficacy.2-4)
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- 3) N1-methyl-pseudouridine in mRNA enhances translation through eIF2α dependent and independent mechanisms by increasing ribosome density
- 4) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
参考文献
Please visit the Pubchem page at this link.
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