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CAS RN: 110429-36-2 | 产品编码: M2645
N-Methyl Paroxetine
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 109.0 to 113.0 °C |
| Specific rotation [a]20/D | -69.0 to -89.0 deg(C=0.01, MeOH) |
物性（参考值）
| 熔点 | 111 °C |
| 比旋光度 [α]D | -70° (C=0.01,MeOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
N-Methyl paroxetine: A Synthetic Precursor of Paroxetine
N-Methyl paroxetine is a synthetic precursor of paroxetine hydrochloride hemihydrate [P1977] which is a 5-hydroxytryptamine (5-HT) uptake inhibitor.
References
- Preparation of crystalline paroxetine hydrochloride hemihydrate for use as an antidepressant
- R. D. Barnes, M. W. Wood-Kaczmar, J. E. Richardson, I. R. Lynch, P. C. Buxton, A. D. Curzons, Eur. Pat. Appl. 1987, EP 223403 A2.
- Preparation of paroxetine from N-alkyl derivatives.
- S.-z. Wang, Y. Matsumura, Eur. Pat. Appl. 1997, EP 810225 A1.
参考文献
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技术规格
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