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CAS RN: 3685-84-5 | 产品编码: M2460
Meclofenoxate Hydrochloride
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| 产品编码 | M2460 |
| 纯度/分析方法 | >98.0%(T) |
| 分子式/分子量 | C__1__2H__1__6ClNO__3·HCl = 294.17 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3685-84-5 |
| 相关CAS RN | 51-68-3 |
| Reaxys-RN | 3637332 |
| PubChem物质ID | 253661831 |
| Merck Index (14) | 5780 |
| MDL编号 | MFCD00012533 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 137.0 to 142.0 °C |
物性（参考值）
| 熔点 | 139 °C |
| 溶解性（可溶于） | 丙酮 |
| 溶解性（不溶于） | 苯, 氯仿, 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | AG0440000 |
运输信息
| HS编码* | 2922.19-000 |
应用
Meclofenoxate Hydrochloride: A Compound Acting as a Precursor of Acetylcholine and a Free-Radical Scavenger
Meclofenoxate, also called centrophenoxine, is the ester made from 4-chlorophenoxyacetic acid [C0250] and 2-(dimethylamino)ethanol (also called dimethylaminoethanol or DMAE) [D0649]. It is reported that meclofenoxate increases the DMAE levels in the brain. DMAE is a precursor of acetylcholine, an important neurotransmitter in the brain. Therefore, meclofenoxate is widely recognized as a nootropic enhancer. In addition, DMAE is also reported as a free-radical scavenger and an antioxidant. (The product is for research purpose only.)
References
- Increases in choline levels in rat brain elicited by meclofenoxate
- On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review
- Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and citicholine (experiments on rats)
- Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine
- Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease
- Kinetic study on the degradation of meclophenoxate hydrochloride in alkaline aqueous solutions by high performance liquid chromatography
- A Simple and Sensitive HPLC Method for Quantification of the Metabolin of Meclofenoxate in Human Plasma
参考文献
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