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CAS RN: 50924-49-7 | 产品编码: M2399
Mizoribine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | M2399 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__9H__1__3N__3O__6 = 259.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50924-49-7 |
| Reaxys-RN | 8155135 |
| PubChem物质ID | 253659680 |
| Merck Index (14) | 6222 |
| MDL编号 | MFCD00057221 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -25.0 to -27.0 deg(C=2,H2O) |
物性（参考值）
| 熔点 | 198 °C(dec.) |
| 比旋光度 [α]D | -26° (C=2,H2O) |
| 最大吸收波长 | 280 nm |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H340 : May cause genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | NI3980000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Mizoribine: An Imidazole Nucleoside Immunosuppressive and Antiviral Agent
Mizoribine (bredinin, MZR), an imidazole nucleoside, is an immunosuppressive and an antiviral agent. The immunosuppressive effect of mizoribine has been reported to be due to the inhibition of de novo guanosine synthesis, via inhibition of inosine-5'-monophosphate dehydrogenase (IMPDH).1-4) On the other hand, the combination of mizoribine and interferon (IFN)-α have been reported to show antiviral activities. The mechanisms of action would appear that mizoribine inhibits virus RNA replication based on the depletion of the intracellular pool of guanosine nucleotides by IMPDH inhibition.5-7) In addition, mizoribine has been reported to its anti-coronavirus activity.８) (The product is for research purpose only.)
References
- 1)Studies on bredinin. I. Isolation, characterization, and biological properties
- 2)Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine
- 3)Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism
- 4)Mizoribine and mycophenolate mofetil (a review)
- 5)Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho-and paramyxoviruses
- 6)Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-α
- 7)Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-α
- 8)Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
参考文献
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