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CAS RN: 72432-03-2 | 产品编码: M2302
Miglitol
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| 产品编码 | M2302 |
| 纯度/分析方法 | >98.0%(GC)(T) |
| 分子式/分子量 | C__8H__1__7NO__5 = 207.23 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 72432-03-2 |
| Reaxys-RN | 5329949 |
| PubChem物质ID | 160871160 |
| Merck Index (14) | 6187 |
| MDL编号 | MFCD00867240 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 144.0 to 148.0 °C |
| Specific rotation [a]20/D | -7.0 to -9.0 deg(C=0.5、H2O) |
物性（参考值）
| 熔点 | 146 °C |
| 比旋光度 [α]D | -8° (C=0.5,H2O) |
| 水溶性 | 可溶 |
GHS
相关法规
| RTECS# | TN4350170 |
运输信息
| HS编码* | 2933.39-000 |
应用
Miglitol: A Pseudo-Monosaccharide α-Glucosidase Inhibitor
Miglitol is a pseudo-monosaccharide α-glucosidase inhibitor. α-Glucosidase (also called maltase) is an enzyme, and catalyzes the hydrolysis of terminal 1,4-linked α-glucose residues of oligosaccharides and disaccharides to a single α-glucose molecule. Miglitol lowers blood sugar by inhibiting the enzyme α-glucosidase in the gastrointestinal tract, resulting in delayed glucose absorption. Recently, it is reported that miglitol suppresses the expression of interleukins which are a group of cytokines that are seen to be expressed by white blood cells (leukocytes). (The product is for research purpose only.)
References
- Pharmacokinetics of miglitol. Absorption, distribution, metabolism, and excretion following administration to rats, dogs, and man
- Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus (a review)
- Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects
- The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus
参考文献
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