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CAS RN: 71-58-9 | 产品编码: M1964
Medroxyprogesterone Acetate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 93.0 % |
| Melting point | 203.0 to 209.0 °C |
| Specific rotation [a]20/D | +45.0 to +51.0 deg(C=1, Dioxane) |
物性（参考值）
| 熔点 | 206 °C |
| 比旋光度 [α]D | 48° (C=1,Dioxane) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（微溶于） | 醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | TU5010000 |
运输信息
| HS编码* | 2937.23-000 |
应用
Medroxyprogesterone acetate: Semi-Synthetic Progestational Agent
Medroxyprogesterone acetate (MPA) and megestrol acetate [M1949], semi-synthetic progestational agents, are effective hormonal treatments for metastatic breast cancer in postmenopausal women. The antineoplastic effect may result from inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion. In addition, MPA has the pregnancy maintaining effect and the anti-estrogen effect. (The product is for research purpose only.)
References
- Pregnancy Maintaining Effect of Synthetic Progestogens in the Rat
- Studies of the So-called Virilizing Effects of Steroids in Female Rat Fetuses
- Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate (a review)
- The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer (a review)
- Determination of the residues of 50 anabolic hormones in muscle, milk and liver by very-high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry
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