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CAS RN: 83-43-2 | 产品编码: M1665
6α-Methylprednisolone
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| 产品编码 | M1665 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__2H__3__0O__5 = 374.48 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 83-43-2 |
| Reaxys-RN | 2340300 |
| PubChem物质ID | 87560014 |
| Merck Index (14) | 6111 |
| MDL编号 | MFCD00010591 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +79.0 to +86.0 deg(C=1, Dioxane) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 237 °C |
| 比旋光度 [α]D | 82° (C=1,Dioxane) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | TU4146000 |
运输信息
| HS编码* | 2937.29-000 |
应用
Methylprednisolone (medrol): A Glucocorticosteroid with Potent Anti-Inflammatory Activities
6α-Methylprednisolone (medrol) is a classified as a glucocorticosteroid which cause profound and varied metabolic effects. In addition, they affect immune system. It is reported that medrol has a more potent anti-inflammatory effect than cortisone [C1317] and hydrocortisone [H0533]. Furthermore, medrol has far less effects of electrolyte as a glucocorticosteroid. (The product is for research purpose only.)
References
- The neuroprotective pharmacology of methylprednisolone (a review)
- The mechanism of action of methylprednisolone in the treatment of multiple sclerosis (a review)
- Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids
- Identification of ten corticosteroids in human hair by liquid chromatography-ionspray mass spectrometry
- Liquid chromatographic-mass spectrometric analysis of 11 glucocorticoid residues and an optimization of enzymatic hydrolysis conditions in bovine liver
参考文献
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