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CAS RN: 84088-42-6 | 产品编码: L0270
Linomide
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 96.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 204 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2933.79-000 |
应用
Roquinimex: An Immunostimulant, Angiogenesis Inhibitor and TNF-α Down-Regulator
Linomide (roquinimex, LS 2616) is a synthetic immunostimulant which increases natural killer (NK) cell activity and macrophage cytotoxicity. Linomide also inhibits angiogenesis and reduces the secretion of tumor necrosis factor-α (TNF-α). Linomide has been investigated as an anti-tumor agent and a type I antidiabetes agent. (The product is for research purpose only.)
References
- Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide)
- Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers
- Potentiation of the antiangiogenic ability of Linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers
- Structure-activity relationships studies of the anti-angiogenic activities of linomide
- The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus (a review)
- Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system (a review)
参考文献
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