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CAS RN: 75706-12-6 | 产品编码: L0250
Leflunomide
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| 产品编码 | L0250 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__2H__9F__3N__2O__2 = 270.21 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 75706-12-6 |
| Reaxys-RN | 4323174 |
| PubChem物质ID | 160871382 |
| Merck Index (14) | 5432 |
| MDL编号 | MFCD00867593 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 166.0 to 170.0 °C |
物性（参考值）
| 熔点 | 168 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 27 mg/l 25 °C |
| 溶解性（可溶于） | 丙酮, 乙醇, 甲醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | NY2354200 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2934.99-000 |
应用
Leflunomide: A Prodrug of Immunoregulatory Agent, Teriflunomide
Leflunomide is a prodrug of teriflunomide [T3287] which has two activites: inhibition of pyrimidine nucleotide synthesis and interference with tyrosine phosphorylation. More specifically, it inhibits the enzymic activity of dihydroorotate dehydrogenase (DHO-DHase) which catalyzes the fourth step in the biosynthesis of pyrimidine, and tyrosine kinases which transfer a phosphate group from ATP to a protein in a cell. Leflunomide reduces the proliferation of T and B immune cells that are active in multiple sclerosis (MS). For your reference, [C3217] is a synthetic intermediate. (The product is for research purpose only.)
References
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase
- Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-κB activation and gene expression
- S. K. Manna, B. B. Aggarwal, J. Immunol. 1999, 162, 2095.
- Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
- Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
参考文献
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