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CAS RN: 112809-51-5 | 产品编码: L0248
Letrozole
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 1G |
S$253.50
|
23 | ≥100 |
|
| 产品编码 | L0248 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__1__1N__5 = 285.31 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 112809-51-5 |
| Reaxys-RN | 6813913 |
| PubChem物质ID | 172089003 |
| Merck Index (14) | 5450 |
| MDL编号 | MFCD00866241 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 183.0 to 187.0 °C |
物性（参考值）
| 熔点 | 185 °C |
| 水溶性 | 不溶 |
| 溶解性（微溶于） | 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P405 : Store locked up. |
相关法规
| RTECS# | DI4957000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Letrozole: A Nonsteroidal, Potent and Selective Aromatase Inhibitor
Letrozole (CGS 20267), exemestane [E0941] and anastrozole [A2370] are third generation, and potent and selective aromatase inhibitors. In postmenopausal women, estrogens are mainly derived from the action of the aromatase which is responsible enzyme for the aromatization of androgens ([A0845] and [T0027]) into estrogens ([E0026] and [E0025]) respectively in the periphery. The growth of the breast cancer is stimulated or maintained by estrogens. Letrozole, exemestane and anastrozole inhibit aromatase and estrogen synthesis, resulting in suppressing tumor growth. (The product is for research purpose only.)
References
- Highly selective inhibition of estrogen biosynthesis by CGS 20267 (Letrozole), a new non-steroidal aromatase inhibitor
- Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial
- Letrozole Inhibits Tumor Proliferation More Effectively than Tamoxifen Independent of HER1/2 Expression Status
- Aromatase inhibitors in the treatment of breast cancer (a review)
- Letrozole: a review of its use in postmenopausal women with advanced breast cancer
- High-performance liquid chromatography of the aromatase inhibitor, letrozole, and its metabolite in biological fluids with automated liquid-solid extraction and fluorescence detection
参考文献
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