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CAS RN: 134678-17-4 | 产品编码: L0217
Lamivudine
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | L0217 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__8H__1__1N__3O__3S = 229.25 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 134678-17-4 |
| Reaxys-RN | 5480511 |
| PubChem物质ID | 87560180 |
| Merck Index (14) | 5352 |
| MDL编号 | MFCD00869739 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 175.0 to 179.0 °C |
| Specific rotation [a]20/D | -137.0 to -147.0 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 177 °C |
| 比旋光度 [α]D | -142° (C=1,MeOH) |
| 水溶性 | 可溶 |
| 在水中的溶解度 | 70,000 mg/l 20 °C |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P314 : Get medical advice/ attention if you feel unwell. |
相关法规
| RTECS# | UW7361333 |
运输信息
| HS编码* | 2934.99-000 |
应用
Lamivudine: An L-Nucleoside Reverse Transcriptase Inhibitor
Lamivudine is a nucleoside reverse transcriptase inhibitor that active against HIV1, HIV2, and hepatitis B. Lamivudine is a synthetic L-nucleoside analogue of the naturally occurring D-nucleoside 2’-deoxycytidine. Intracellularly, lamivudine is converted by cellular enzymes to the active metabolite, lamivudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxycytidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine
- Lamivudine A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
- New and Emerging Treatment of Chronic Hepatitis B (a review)
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