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CAS RN: 74050-98-9 | 产品编码: K0051
Ketanserin
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| 产品编码 | K0051 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__2H__2__2FN__3O__3 = 395.43 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 74050-98-9 |
| Reaxys-RN | 4913068 |
| PubChem物质ID | 253661148 |
| Merck Index (14) | 5296 |
| MDL编号 | MFCD00083392 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 231.0 to 235.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 233 °C |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 10 mg/l |
| 溶解性（微溶于） | 二甲基甲酰胺 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | VA1411190 |
运输信息
| HS编码* | 2933.59-000 |
应用
Ketanserin: A Selective 5-HT2a Receptor Antagonist with Weak α1-Adrenoceptor Antagonistic Activity
Ketanserin is a selective 5-HT2a receptor antagonist. 5-HT receptors can be divided into some receptor subtypes. Ketanserin is used for discrimination between 5-HT receptor subtypes. Ketanserin also has weak α1-adrenoceptor antagonistic activity which may explain its antihypertensive mechanism of action. Ketanserin inhibits the effects of serotonin on platelets, and inhibits vasoconstriction caused by the catecholamine. (The product is for research purpose only.)
References
- Ketanserin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease
- Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes
- Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions
- Ketanserin and spiperone as templates for novel serotonin 5-HT2A antagonists (a review)
- Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin (a review)
参考文献
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