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CAS RN: 160807-49-8 | 产品编码: I1118
Indirubin-3'-monoxime
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纯度/分析方法: >98.0%(HPLC)
别名：
- 靛玉红-3'-单肟
- 3-(异亚硝基)-[2,3'-二吲哚啉亚基]-2'-酮
- 3-[1,3-二氢-3-(异亚硝基)-(2H)-吲哚-2-亚基]-1,3-二氢-(2H)-吲哚-2-酮
- 靛玉红-3'-肟
- 3-(Hydroxyimino)[2,3'-biindolinylidene]-2'-one
- 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
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产品文档：
| 产品编码 | I1118 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__6H__1__1N__3O__2 = 277.28 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| CAS RN | 160807-49-8 |
| Reaxys-RN | 10094715 |
技术规格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 239.0 to 243.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 241 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.79-000 |
应用
Indirubin-3'-monoxime: A Non-Specific Protein Kinase Inhibitor
Indirubin [I0868] is an active constituent of the traditional Chinese Medicine Danggui Longhui Wan which is used for years in the treatment of chronic myelocytic leukemia.1) Indirubin-3'-monoxime is a cell permeable derivative of indirubin, and a potent inhibitor of cyclin-dependent kinases (CDK) and glycogen synthase kinase-3β (GSK3β).1,2) There are reports that indirubin-3'-monoxime induce apoptosis and tumor cell death in transitional cell cancer cell lines.3) Indirubin-3'-monoxime also inhibits LRRK2 (leucine-rich repeat kinase 2) that is a promising therapeutic target for the treatment of Parkinson's disease.4,5) (The product is for research purpose only.)
References
- 1) Indirubin, the active constituent of a Chinese antileukemia medicine, inhibits cyclin-dependent kinases
- 2) GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
- 3) Antiproliferative and apoptosis inducing effects of indirubin-3'-monoxime in renal cell cancer cells
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- 5) Development of LRRK2 Inhibitors for the Treatment of Parkinson’s Disease (a review)
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