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CAS RN: 521984-48-5 | 产品编码: I1110
SIS 3 Hydrochloride
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纯度/分析方法: >98.0%(HPLC)
别名：
- SIS 3 盐酸盐
- (E)-1-[6,7-二甲氧基-3,4-二氢异喹啉-2(1H)-基]-3-(1-甲基-2-苯基-1H-吡咯并[2,3-b]吡啶-3-基)丙-2-烯-1-酮盐酸盐
- (E)-1-[6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one Hydrochloride
产品文档：
| 产品编码 | I1110 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__8H__2__7N__3O__3·HCl = 490.00 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| CAS RN | 521984-48-5 |
| PubChem物质ID | 468592101 |
| MDL编号 | MFCD09265258 |
技术规格
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2933.49-000 |
应用
SIS3 Hydrochloride: a specific inhibitor of Smad3
SIS3 hydrochloride is a specific inhibitor of Smad3 which has been reported as a key downstream effector of transforming growth factor-β (TGF-β) signaling in tissue fibrogenesis, and a key player in progression of fibrosis. Therefore, SIS3 has been expected as an agent for the treatment of fibrosis. (The product is for research purpose only.)
References
- Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression
- The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling
- SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice
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