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CAS RN: 123663-49-0 | 产品编码: I0945
Iguratimod
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 艾拉莫德
- N-(3-甲酰氨基-4-氧-6-苯氧基-4H-色满-7-基)甲烷磺酰胺
- N-[7-(甲烷磺酰氨基)-4-氧-6-苯氧基-4H-色满-3-基]甲酰胺
- N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide
- N-[7-(Methanesulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl]formamide
产品文档：
| 产品编码 | I0945 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__1__4N__2O__6S = 374.37 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 123663-49-0 |
| Reaxys-RN | 8640145 |
| PubChem物质ID | 253660421 |
| MDL编号 | MFCD00882374 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 238.0 to 242.0 °C |
物性（参考值）
| 熔点 | 240 °C |
| 水溶性 | 不溶 |
| 溶解性（不溶于） | 乙醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Iguratimod (T-614): An Agent with Anti-Inflammatory and Immunomodulatory Activities
Iguratimod (T-614) is an agent with anti-inflammatory and immunomodulatory activities. Iguratimod inhibits the production of immune globulin and inflammatory cytokines such as TNF-α, IL-1β and IL-6 in vitro. Even though the mechanism of action of iguratimod is still not fully understood, the suppression of nuclear factor kappa B (NF-κB) activation has been indicated. Iguratimod is used as a disease modifying anti-rheumatic drug (DMARD). (The product is for research purpose only.)
References
- Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one. 1st Communication: antiinflammatory, analgesic and other related properties
- K. Tanaka, T. Shimotori, S. Makino, Y. Aikawa, T. Inaba, C. Yoshida, S. Takano, Arzneim.-Forsch. 1992, 42, 935.
- Synthesis and antiinflammatory activity of 7-methanesulfonylamino-6-phenoxychromones. Antiarthritic effect of the 3-formylamino compound (T-614) in chronic inflammatory disease models
- An anti-rheumatic agent T-614 inhibits NF-κB activation in LPS- and TNF-α-stimulated THP-1 cells without interfering with IκBα degradation
- Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice
- Determination of iguratimod in rat plasma by high performance liquid chromatography: method and application
参考文献
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