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CAS RN: 89396-94-1 | 产品编码: I0901
Imidapril Hydrochloride
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 咪达普利盐酸盐
- 盐酸咪达普利
- (4S)-3-[(2S)-2-[[(1S)-1-(乙氧基羰基)-3-苯丙基]氨基]-1-氧丙基]-1-甲基-2-氧-4-咪唑啉盐酸盐
- (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Acid Hydrochloride
产品文档：
| 产品编码 | I0901 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__7N__3O__6·HCl = 441.91 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 89396-94-1 |
| 相关CAS RN | 89371-37-9 |
| Reaxys-RN | 4835331 |
| PubChem物质ID | 253661853 |
| Merck Index (14) | 4911 |
| MDL编号 | MFCD00923828 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -65.0 to -69.0 deg(C=1, MeOH) |
物性（参考值）
| 熔点 | 206 °C(dec.) |
| 比旋光度 [α]D | -67° (C=1,MeOH) |
| 水溶性 | 可溶 |
| 溶解性（微溶于） | 乙醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | NI8927400 |
运输信息
| HS编码* | 2933.29-000 |
应用
Imidapril Hydrochloride: A Non-Sulfhydryl Group and Long-Acting ACE Inhibitor
Imidapril hydrochloride is an ethyl ester prodrug of the active metabolite imidaprilat. Imidapril is a long-acting and non-sulfhydryl group drug with fewer side effects angiotensin-converting enzyme (ACE) inhibitor to suppress the conversion of angiotensin I to angiotensin II and thereby reduce total peripheral resistance (TRP) and systemic blood pressure (BP). (The product is for research purpose only.)
References
- Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor (a review)
- Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin-converting enzyme inhibitors. An update (a review)
- Imidapril: a review of its use in essential hypertension, type 1 diabetic nephropathy and chronic heart failure
- Imidapril: will fewer adverse events translate into better long-term outcomes? (a review)
参考文献
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