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CAS RN: 70288-86-7 | 产品编码: I0819
Ivermectin
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | I0819 |
| 纯度/分析方法 | >93.0%(HPLC) |
| 分子式/分子量 | C__4__8H__7__4O__1__4 = 875.11 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 70288-86-7 |
| Reaxys-RN | 8400552 |
| PubChem物质ID | 468592054 |
| Merck Index (14) | 5248 |
| MDL编号 | MFCD00869511 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 93.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 155 °C |
| 溶解性（可溶于） | 二乙醚, 乙醇, 甲醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P273 : Avoid release to the environment. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | IH7891500 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | I |
| HS编码* | 2932.20-000 |
应用
Autophagy research / Mitophagy research
References
- Ivermectin induces mitophagy in H9c2 cells via activation of the PINK1/Parkin pathway
- Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform
应用
Ivermectin: A Semisynthetic Anthelmintic Agent with Antiviral Activity
Ivermectin is a semisynthetic anthelmintic agent derived from the avermectins isolated from the fermentation products of Streptomyces avermitilis.1,2) Ivermectin contains B1a (C48H74O14) and B1b (C47H72O14), but the main component is B1a as shown in the figure. The mechanism of action of ivermectin is not fully understood, but it is strongly suggested to be related to glutamate-gated chloride channels in the muscles and nerves of nematode.2) Ivermectin binds with high affinity to glutamatergic chloride channels of nematode. As the result, the nematode is thought to be paralyzed. In addition, it has recently been reported that ivermectin has a broad spectrum of antiviral activity in vitro, including SARS-CoV-2.3,4) (The product is for research purpose only.)
References
- 1) Ivermectin 'Wonder drug' from Japan: the human use perspective (a review)
- 2) Ivermectin - Old Drug, New Tricks? (a review)
- 3) Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture
- 4) The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
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