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CAS RN: 19235-17-7 | 产品编码: H1863
5-(Hydroxymethyl)cytidine
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纯度/分析方法: >95.0%(HPLC)
别名：
- 5-(羟甲基)胞苷
- 5-羟甲基胞苷
- 4-氨基-1-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基]-5-(羟甲基)嘧啶-2(1H)-酮
- 5-Hydroxymethylcytidine
- 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(hydroxymethyl)pyrimidin-2(1H)-one
产品文档：
| 产品编码 | H1863 |
| 纯度/分析方法 | >95.0%(HPLC) |
| 分子式/分子量 | C__1__0H__1__5N__3O__6 = 273.25 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 19235-17-7 |
| Reaxys-RN | 553746 |
| MDL编号 | MFCD26523159 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 214.0 to 218.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 216 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
5-(Hydroxymethyl)cytidine: An Important Base-modified Ribonucleoside in Epigenetics
5-(Hydroxymethyl)cytidine (hm5C) is a modified ribonucleoside that has long been known to be present in mRNA, tRNA, and rRNA. 5-(Hydroxymethyl)cytidine in RNA is generated by 5-methylcytidine (m5C) [M1931] oxidation in vivo. Recent studies have discovered that 5-(hydroxymethyl)cytidine is a prevalent mRNA modification in eukaryotes and has roles in cell viability and development through these effects on RNA as follows; RNA structure and translation efficiency.1,2) In addition, 5-(hydroxymethyl)cytidine has been reported to have important functions in the nervous system.3-5)
References
- 1) Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
- 2) Formation and Abundance of 5-Hydroxymethylcytosine in RNA
- 3) Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
- 4) Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
- 5) Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
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