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CAS RN: 155558-32-0 | 产品编码: H1745
Hydroxyfasudil Hydrochloride
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| 产品编码 | H1745 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__4H__1__7N__3O__3S·HCl = 343.83 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿),加热 |
| CAS RN | 155558-32-0 |
| PubChem物质ID | 468592024 |
| MDL编号 | MFCD06411567 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Water | max. 7.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 299 °C(dec.) |
GHS
相关法规
运输信息
| HS编码* | 2935.90-000 |
应用
Hydroxyfasudil Hydrochloride: An Active Metabolite of Fasudil, a Rho Kinase Inhibitor
Hydroxyfasudil hydrochloride is an active metabolite of fasudil [F0839 (HCl salt)], which is a potent and selective Rho kinase (a protein phosphatase) inhibitor. Hydroxyfasudil inhibits phosphorylation of myosin light chain, the final step in the vascular smooth muscle contractile mechanism, by inhibiting Rho kinase. Fasudil has been used as a vasodilator for the treatment of cerebral vasospasm. (The product is for research purpose only.)
References
- Pharmacological profile of hydroxyfasudil as a selective rho kinase inhibitor on ischemic brain damage
- Hydroxyfasudil, and active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase
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