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CAS RN: 102518-79-6 | 产品编码: H1700
(-)-Huperzine A
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| 产品编码 | H1700 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__5H__1__8N__2O = 242.32 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 102518-79-6 |
| Reaxys-RN | 3592896 |
| PubChem物质ID | 468591999 |
| Merck Index (14) | 4755 |
| MDL编号 | MFCD01714949 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 228.0 to 233.0 °C |
| Specific rotation [a]20/D | -144 to -155 deg(C=0.5, MeOH) |
| Water | max. 3.0 % |
物性（参考值）
| 熔点 | 232 °C |
| 比旋光度 [α]D | -147° (C=0.5,MeOH) |
| 最大吸收波长 | 313(EtOH) nm |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | PB9185700 |
运输信息
| UN编号 | UN1544 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2939.79-000 |
应用
(-)-Huperzine A: A Potent, Highly Specific and Reversible Inhibitor of Acetylcholinesterase
(-)-Huperzine A (HupA), a Lycopodium alkaloid isolated from the Chinese herb Huperzia Serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). It has been reported that HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action, compared with other AChE inhibitors including donepezil [D4099] and rivastigmine [R0093]. Recently, HupA has been used in Alzheimer's disease and other forms of dementia. (The product is for research purpose only.)
References
- The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
- Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
- The Lycopodium alkaloids (a review)
- Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
- Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research
- Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma
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