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CAS RN: 14047-28-0 | 产品编码: H1291
(R)-9-(2-Hydroxypropyl)adenine

产品编码 | H1291 |
纯度/分析方法 | >98.0%(T)(HPLC) |
分子式/分子量 | C__8H__1__1N__5O = 193.21 |
外观与形状(20°C) | 固体 |
储存温度 | 室温 (15°C以下阴凉干燥处) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 湿气 (分解) |
包装和容器 | 1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 14047-28-0 |
PubChem物质ID | 253662428 |
MDL编号 | MFCD07369451 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 198.0 to 202.0 °C |
Specific rotation [a]20/D | -41.0 to -46.0 deg(C=1,EtOH) |
NMR | confirm to structure |
物性(参考值)
熔点 | 200 °C |
比旋光度 [α]D | -42° (C=1,EtOH) |
溶解性(可溶于) | 二甲基甲酰胺 |
GHS
象形图 |
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信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2933.99-000 |
应用
An Intermediate for the Synthesis of Tenofovir, a Nucleotide Reverse Transcriptase Inhibitor
This compound is an intermediate for the synthesis of tenofovir [T3006], a nucleotide reverse transcriptase (RT) inhibitor and antiretroviral agent.
References
- Synthesis of enantiomeric N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. I. The stepwiseapproach
- Practical synthesis of the anti-HIV drug, PMPA
- Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale
- The synthesis of tenofovir and its analogues via asymmetric transfer hydrogenation
参考文献
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