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CAS RN: 127-07-1 | 产品编码: H0310
Hydroxyurea
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 140 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H340 : May cause genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | YT4900000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2928.00-000 |
应用
Adeno-associated virus vector transduction enhancer
Hydroxyurea increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors
应用
Hydroxyurea (or hydroxycarbamide): A Ribonucleotide Reductase Inhibitor
Hydroxyurea (or hydroxycarbamide), a hydroxylated molecule of urea [U0077][U0073], is classified as an antitumor antimetabolite. Hydroxyurea inhibits deoxynucleotide and DNA synthesis by blocking the cellular enzyme ribonucleotide reductase, which is responsible for producing the deoxynucleotides required for DNA synthesis and repair, producing cell death in S phase (the phase of DNA synthesis). Recently, two effects of hydroxyurea have been reported: hydroxyurea increases the level of fetal hemoglobin, leading to a reduction in the incidence of vaso-occlusive crises in sickle cell anemia, and hydroxyurea inhibits human immunodeficiency virus-type 1 (HIV-1) DNA synthesis. (The product is for research purpose only.)
References
- Mechanism of action of hydroxyurea (a review)
- Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
- Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
- Pharmacokinetics and pharmacodynamics of hydroxyurea (a review)
- Nitric oxide production from hydroxyurea (a review)
- Colorimetric determination of hydroxyurea in human serum using high-performance liquid chromatography
参考文献
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