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CAS RN: 278779-30-9 | 产品编码: G0648
GW 4064
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纯度/分析方法: >95.0%(HPLC)(qNMR)
别名：
- 3-[2-氯-4-[[3-(2,6-二氯苯基)-5-异丙基异噁唑-4-基]甲氧基]苯乙烯基]苯甲酸
- 3-[2-[2-氯-4-[[3-(2,6-二氯苯基)-5-异丙基-1,2-噁唑-4-基]甲氧基]苯基]乙烯基]苯甲酸
- 3-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy]styryl]benzoic Acid
- 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methoxy]phenyl]vinyl]benzoic Acid
产品文档：
| 产品编码 | G0648 |
| 纯度/分析方法 | >95.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__2__8H__2__2Cl__3NO__4 = 542.84 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,湿气 (吸湿),加热 |
| CAS RN | 278779-30-9 |
| Reaxys-RN | 10125635 |
| MDL编号 | MFCD09971006 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 173.0 to 177.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 175 °C |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
GW 6064: The First Non-Steroidal and Selective Farnesoid X Receptor (FXR) Agonist
The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor (BAR) expressed primarily in the liver and intestine.1) FXR plays important roles not only in bile acid, lipid metabolism, and carbohydrate homeostasis, but also in inflammatory responses.2) GW 6064 is the first non-steroidal and selective FXR agonist with decent submicromolar potency and has been used to study the role of FXR in dyslipidemia, diabetes, obesity and cancer.2,3) (The product is for research purpose only.)
References
- 1) Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets
- 2) Role of farnesoid X receptor in inflammation and resolution (a review)
- 3) Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
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技术规格
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