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CAS RN: 18865-38-8 | 产品编码: G0579
Glycinexylidide
产品编码 | G0579 |
纯度/分析方法 | >98.0%(HPLC) |
分子式/分子量 | C__1__0H__1__4N__2O = 178.24 |
外观与形状(20°C) | 固体 |
储存温度 | 室温 (15°C以下阴凉干燥处) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 空气 |
包装和容器 | 250MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 18865-38-8 |
Reaxys-RN | 2416240 |
PubChem物质ID | 468591946 |
MDL编号 | MFCD05267700 |
技术规格
Appearance | White to Light yellow powder to crystaline |
Purity(HPLC) | min. 98.0 area% |
Melting point | 89.0 to 93.0 °C |
NMR | confirm to structure |
物性(参考值)
熔点 | 92 °C |
GHS
象形图 | |
信号词 | Warning |
危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
HS编码* | 2924.29-000 |
应用
Glycinexylidide: An Active Metabolite of Lidocaine
Glycinexylidide is an active metabolite of lidocaine [L0156] which is metabolized in the liver into two active compounds, glycinexylidide and monoethylglycinexylidide [N1171]. The major metabolic pathway, sequential N-deethylation to them, is primarily mediated by CYP1A2. Therefore, glycinexylidide has been used to assess liver function. (The product is for research purpose only.)
References
- Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function
- High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine
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