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CAS RN: 95058-81-4 | 产品编码: G0544
Gemcitabine
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| 产品编码 | G0544 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__9H__1__1F__2N__3O__4 = 263.20 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 95058-81-4 |
| 相关CAS RN | 122111-03-9 |
| Reaxys-RN | 5382060 |
| PubChem物质ID | 468591927 |
| Merck Index (14) | 4386 |
| MDL编号 | MFCD00869720 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 217.0 to 222.0 °C |
| Specific rotation [a]20/D | 70.0 to 78.0 deg(C=1,MeOH) |
物性（参考值）
| 熔点 | 219 °C |
| 比旋光度 [α]D | 74° (C=1,MeOH) |
| 最大吸收波长 | 268 nm (EtOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | HA3835000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Autophagy research / Mitophagy research
References
- Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
应用
Gemcitabine: A Fluorinated Deoxycytidine Analog with Antitumor Activity
Gemcitabine and its hydrochloride [G0367] are fluorinated deoxycytidine analogs with antitumor activity against solid tumors. Once inside the cell, gemcitabine is rapidly phosphorylated by deoxycytidine kinase to form the active metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCDP inhibits ribonucleotide reductase, which is responsible for producing the deoxynucleotides required for DNA synthesis and repair. dFdCTP can be incorporated into DNA, leading to inhibition of DNA synthesis, producing cell death in S phase (the phase of DNA synthesis). On the other hand, a concomitant treatment with gemcitabine and cisplatin [D3371] is used for the treatment of several different types of cancer. Cisplatin acts by formation of platinum (Pt)-DNA adducts; gemcitabine acts by dFdCTP incorporation into DNA, subsequently leading to inhibition of exonuclease and DNA repair. (The product is for research purpose only.)
References
- Gemcitabine: metabolism, mechanisms of action, and self-potentiation (a review)
- Gemcitabine. A review of its pharmacology and clinical potential in non-small-cell lung cancer and pancreatic cancer
- Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine) (a review)
- Synergistic interaction between cisplatin and gemcitabine in vitro
- Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid chromatography with ultraviolet detection
- Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry
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