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CAS RN: 6902-91-6 | 产品编码: G0519
Germacrone
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纯度/分析方法: >98.0%(GC)
别名：
- 吉马酮
- (E,E)-吉马-3,7(11),9-三烯-6-酮
- 反,反-3,7-二甲基-10-异亚丙基-3,7-环癸二烯-1-酮
- (3E,7E)-3,7-二甲基-10-(丙-2-亚基)环癸-3,7-二烯酮
- (E,E)-Germacra-3,7(11),9-trien-6-one
- trans,trans-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
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产品文档：
| 产品编码 | G0519 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__1__5H__2__2O = 218.34 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 6902-91-6 |
| Reaxys-RN | 2047453 |
| PubChem物质ID | 354335190 |
| MDL编号 | MFCD00210050 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 54.0 to 58.0 °C |
物性（参考值）
| 熔点 | 56 °C |
| 最大吸收波长 | 309 nm (MeOH) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | GU2210000 |
运输信息
| HS编码* | 2914.29-000 |
应用
Germacrone: A Component in Curcumae Rhizoma with a Wide Range of Biological Activities
Germacrone is one of the main bioactive components in the traditional Chinese medicine Curcumae Rhizoma.1-3) It has been shown to possess a wide range of biological activities, such as antitumor, anti-inflammatory, immunomodulatory, and antivirus properties.4-7) In addition, syntheses of bioactive substances from germacrone have been reported.7,8) (The product is for research purpose only.)
References
- 1)Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry
- 2)Preparative isolation and purification of germacrone and curdione from the essential oil of the rhizomes of Curcuma wenyujin by high-speed counter-current chromatography
- 3)Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry
- 4)Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
- 5)Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis
- 6)Germacrone inhibits early stages of influenza virus infection
- 7)Germacrone: occurrence, synthesis, chemical transformations and biological properties (a review)
- 8)Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone
参考文献
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