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CAS RN: 10238-21-8 | 产品编码: G0382
Glibenclamide
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.5 area% |
| Purity(Neutralization titration) | min. 98.5 % |
| Melting point | 172.0 to 176.0 °C |
物性（参考值）
| 熔点 | 174 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 二甲基甲酰胺 |
| 溶解性（微溶于） | 乙醇, 甲醇 |
GHS
相关法规
| RTECS# | YS4725200 |
运输信息
| HS编码* | 2935.90-000 |
应用
Glibenclamide: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Glibenclamide belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. Recently, a combination agent with metformin [M2009] is also used for the treatment of Type 2 diabetes. (The product is for research purpose only.)
References
- Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects (a review)
- Sulfonylurea receptor 2B and Kir6.1 form a sulfonylurea-sensitive but ATP-insensitive K+ channel
- Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide
- Sulfonylurea stimulation of insulin secretion (a review)
- Glyburide/metformin tablets: a new therapeutic option for the management of Type 2 diabetes (a review)
- The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
- Simultaneous estimation of six anti-diabetic drugs-glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay
- Liquid chromatography tandem mass spectrometry method for simultaneous determination of antidiabetic drugs metformin and glyburide in human plasma
参考文献
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