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CAS RN: 60456-23-7 | 产品编码: G0364
(S)-(-)-Glycidol
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技术规格
| Appearance | Colorless to Light orange to Yellow clear liquid |
| Purity(GC) | min. 96.0 % |
| Optical purity(GC) | min. 97.0 ee% |
物性（参考值）
| 沸点 | 67 °C/19 mmHg |
| 闪点 | 72 °C |
| 比重 | 1.12 |
| 比旋光度 [α]D | -15° (neat) |
| 折射率 | 1.43 |
| 水溶性 | 完全混溶 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H331 : Toxic if inhaled. H302 + H312 : Harmful if swallowed or in contact with skin. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. H335 : May cause respiratory irritation. H227 : Combustible liquid. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
相关法规
| RTECS# | RR0508100 |
运输信息
| UN编号 | UN2810 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2910.90-000 |
应用
Regioselective epoxide opening Grignard reaction with vinylmagnesium bromide
Typical procedure: To a cooled solution (0 °C) of (S)-glycidol (5.0 g) and imidazole (5.97 g) in CH2Cl2 (250 mL) under N2 was added TBDPSCl (18.55 g) diluted in CH2Cl2 (20 mL). The solution was allowed to warm to room temperature and stirred for 1.5 h. The white slurry was quenched by the addition of water. The organic layer washed with brine, dried over Na2SO4, and concentrated to give TBDPS-(S)-glycidol (21.1g, quant.) of colorless oil which was used directly at the next step. The TBDPS-(S)-glycidol and CuI (1.29 g) in THF (40 mL) under N2 was added dropwise vinylmagnesium bromide (338 mL, 1 M in THF) at -25 °C. After stirring 1 h at -25 °C, the reaction was quenched with sat. NH4Cl solution (400 mL). After warming to room temperature, 5 % aqueous H2SO4 was added to dissolve the salts and the mixture was extracted with Et2O (400 mL). The organic layer was washed with sat. NaHCO3 and brine, dried over Na2SO4. The solution was decanted and concentrated. The residue was purified by column chromatography to give the desired alcohol as a colorless oil (19.3g, 84 %).
References
参考文献