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CAS RN: 82410-32-0 | 产品编码: G0315
Ganciclovir
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Drying loss | max. 4.0 % |
物性（参考值）
| 熔点 | 250 °C(dec.) |
| 在水中的溶解度 | 4.3 g/l 25 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. H340 : May cause genetic defects. H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | MF8407000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Ganciclovir: A 2’-Deoxyguanosine Analogue with Antiviral Activity against Herpes Viruses including Cytomegalovirus
Ganciclovir is a synthetic analogue of 2’-deoxyguanosine with antiviral activity against members of the herpes group such as cytomegalovirus (CMV) and some other DNA viruses. In CMV-infected cells, ganciclovir is initially phosphorylated to its monophosphate by the viral protein kinase, pUL97. Subsequently, the monophosphate s converted to ganciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, ganciclovir interfere with herpes viral DNA synthesis and replication. As the mono-phosphorylation is largely dependent on the viral kinase, mono-phosphorylation of ganciclovir occurs preferentially in virus-infected cells. For your reference, N-Acetyl-di-O-acetylganciclovir [A3228] is a synthetic intermediate of ganciclovir. (The product is for research purpose only.)
References
- Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections
- Antiviral activity and mechanism of action of ganciclovir (a review)
- A protein kinase homolog controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
- Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1
- Antiviral drug resistance of human cytomegalovirus (a review)
应用
Studies of Gene Therapy in Cancer Research
References
- In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
- The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified
- S. M. Freeman, C. N. Abboud, K. A. Whartenby, C. H. Packman, D. S. Koeplin, F. L. Moolten, G. N. Abraham, Cancer Res. 1993, 53, 5274.
- Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
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技术规格
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