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CAS RN: 1953-04-4 | 产品编码: G0293
Galantamine Hydrobromide
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| 产品编码 | G0293 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__2__1NO__3·HBr = 368.27 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,湿气 (吸湿),加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1953-04-4 |
| 相关CAS RN | 357-70-0 |
| Reaxys-RN | 3787265 |
| PubChem物质ID | 87558740 |
| Merck Index (14) | 4340 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -92.0 to -98.0 deg(C=1.4, H2O) |
物性（参考值）
| 熔点 | 256 °C |
| 比旋光度 [α]D | -95° (C=1.4,H2O) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | DF8045500 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2939.79-000 |
应用
Galantamine Hydrobromide: A Unique Dual Mode Agent, an Inhibitor of Acetylcholinesterase and an Allosteric Modulator of Nicotinic Acetylcholine Receptors
Galantamine, a tertiary alkaloid found in the bulbs of Galanthus woronowi. Galantamine increases the concentration of acetylcholine (ACh) in brain tissue through competitive and reversible inhibition of its hydrolysis by acetylcholinesterase (AChE). Besides, galantamine stimulates nicotinic acetylcholine receptors (nAChR) as an allosteric potentiating ligand (APL) to enhance brain cholinergic function. Therefore, galantamine has shown potential for the treatment of Alzheimer's disease. Galantamine is metabolized in the liver via cytochrome P450 enzymes CYP2D6 and CYP3A4. (The product is for research purpose only.)
References
- Galantamine - a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease (a review)
- Galanthamine, a natural product for the treatment of alzheimer's disease (a review)
- Synthesis and pharmacology of galantamine
参考文献
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