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CAS RN: 506-93-4 | 产品编码: G0164
Guanidine Nitrate
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 25G |
S$49.50
|
14 | ≥40 | 下单后约2周内可以发货 |
|
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 212.0 to 216.0 °C |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 214 °C |
| 溶解性（可溶于） | 醇 |
| 溶解性（不溶于） | 乙醚, 苯, 丙酮 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H272 : May intensify fire; oxidizer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P220 : Keep/Store away from clothing/ combustible materials. P210 : Keep away from heat. P221 : Take any precaution to avoid mixing with combustibles. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | MF4350000 |
运输信息
| UN编号 | UN1467 |
| 类别 | 5.1 |
| 包装类别 | III |
| HS编码* | 2925.29-000 |
应用
Nitration of Aryl Compounds
Typical Procedure:
To a well-stirred mixture of aromatic compound (0.01 mol) and 85% sulfuric acid (15 mL) is slowly added guanidine nitrate (1.22 g, 0.01 mol) while maintaining the temperature at 0-5 ℃. After the addition of guanidine nitrate is complete, the mixture is stirred for an additional 0.5-3 h at the same temperature or at rt (for Entry 4). The reaction mixture is poured onto ice water (100 mL) and in the case of Entry 3, it is poured onto ice cold 20% NaOH solution (100 mL). The solid obtained is filtered, washed thoroughly with water and dried. Where solid is not obtained, the aqueous layer is extracted with CHCl3 (4 x 50 mL). The combined CHCl3 layer is washed with 10% Na2CO3 (2 x 25 mL), water (2 x 25 mL) and then dried (anhyd. Na2SO4). After evaporation of the solvent, a brown residue is obtained, which is purified by column chromatography to afford the corresponding nitro compound.
To a well-stirred mixture of aromatic compound (0.01 mol) and 85% sulfuric acid (15 mL) is slowly added guanidine nitrate (1.22 g, 0.01 mol) while maintaining the temperature at 0-5 ℃. After the addition of guanidine nitrate is complete, the mixture is stirred for an additional 0.5-3 h at the same temperature or at rt (for Entry 4). The reaction mixture is poured onto ice water (100 mL) and in the case of Entry 3, it is poured onto ice cold 20% NaOH solution (100 mL). The solid obtained is filtered, washed thoroughly with water and dried. Where solid is not obtained, the aqueous layer is extracted with CHCl3 (4 x 50 mL). The combined CHCl3 layer is washed with 10% Na2CO3 (2 x 25 mL), water (2 x 25 mL) and then dried (anhyd. Na2SO4). After evaporation of the solvent, a brown residue is obtained, which is purified by column chromatography to afford the corresponding nitro compound.
References
- Guanidinium nitrate: a novel reagent for aryl nitrations
参考文献