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CAS RN: 152121-47-6 | 产品编码: F0864
SB 203580
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| 产品编码 | F0864 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__1__6FN__3OS = 377.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 152121-47-6 |
| Reaxys-RN | 7599740 |
| PubChem物质ID | 468591804 |
| MDL编号 | MFCD00922198 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 243.0 to 247.0 °C |
| Elemental analysis(Nitrogen) | 10.60 to 11.60 % |
物性（参考值）
| 熔点 | 245 °C |
GHS
相关法规
| RTECS# | UT3967600 |
运输信息
| HS编码* | 2933.39-000 |
应用
SB 203580: A Cell-Permeable and Specific p38 MAPK Inhibitor
Mitogen-activated protein kinase (MAPK) mediate signal transduction from cell surface receptors to the nucleus. p38 MAPK, a subtype of MAPK, is activated responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. SB 203580 is a cell-permeable p38 MAPK inhibitor that specifically blocks its kinase activity. Therefore, SB 203580 is widely used to elucidate the role of p38 MAPK in a wide array of biological systems.
References
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
- Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
- p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials (a review)
- Roles of p38 MAPKs in invasion and metastasis (a review)
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